Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy

Dilated cardiomyopathy (DCM) due to mutations in RBM20, a gene encoding an RNA-binding protein, is associated with high familial penetrance, risk of progressive heart failure and sudden death. Although genetic investigations and physiological models have established the linkage of RBM20 with early-o...

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Autores principales: Beraldi, Rosanna, Li, Xing, Martinez Fernandez, Almudena, Reyes, Santiago, Secreto, Frank, Terzic, Andre, Olson, Timothy M., Nelson, Timothy J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065152/
https://ncbi.nlm.nih.gov/pubmed/24584570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu091
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