Attenuation of Monocrotaline-Induced Pulmonary Hypertension by Luminal Adeno-Associated Virus Serotype 9 Gene Transfer of Prostacyclin Synthase

Idiopathic pulmonary arterial hypertension (iPAH) is associated with high morbidity and mortality. We evaluated whether luminal delivery of the human prostacyclin synthase (hPGIS) cDNA with adeno-associated virus (AAV) vectors could attenuate PAH. AAV serotype 5 (AAV5) and AAV9 vectors containing th...

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Autors principals: Gubrij, Igor B., Martin, Sara Rebecca, Pangle, Amanda K., Kurten, Richard, Johnson, Larry G.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064732/
https://ncbi.nlm.nih.gov/pubmed/24512101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.187
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