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Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats

To determine whether the antilipogenic actions of insulin-induced gene 1 (insig-1) demonstrated in cultured preadipocytes also occur in vivo, we infected Zucker diabetic fatty (ZDF) (fa/fa) rats, with recombinant adenovirus containing insig-1 or -2 cDNA. An increase of both proteins appeared in thei...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Takaishi, Kiyosumi, Duplomb, Laurence, Wang, May-Yun, Li, Jinping, Unger, Roger H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC406473/
https://ncbi.nlm.nih.gov/pubmed/15096598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401715101
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