Nfatc2 and Tob1 Have Non-Overlapping Function in T Cell Negative Regulation and Tumorigenesis

Nfatc2 and Tob1 are intrinsic negative regulators of T cell activation. Nfatc2-deficient and Tob1-deficient T cells show reduced thresholds of activation; however, whether these factors have independent or overlapping roles in negative regulation of T cell responses has not been previously examined....

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Detalhes bibliográficos
Main Authors: May, Sarah L., Zhou, Qing, Lewellen, Mitzi, Carter, Cristan M., Coffey, David, Highfill, Steven L., Bucher, Christoph M., Matise, Ilze, Morse, Herbert C., O’Sullivan, M. Gerard, Schutten, Melissa, Johnson, Charles, Bellgrau, Donald, Blazar, Bruce R., Modiano, Jaime F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063948/
https://ncbi.nlm.nih.gov/pubmed/24945807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100629
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