Nfatc2 and Tob1 Have Non-Overlapping Function in T Cell Negative Regulation and Tumorigenesis

Nfatc2 and Tob1 are intrinsic negative regulators of T cell activation. Nfatc2-deficient and Tob1-deficient T cells show reduced thresholds of activation; however, whether these factors have independent or overlapping roles in negative regulation of T cell responses has not been previously examined....

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Bibliographic Details
Main Authors: May, Sarah L., Zhou, Qing, Lewellen, Mitzi, Carter, Cristan M., Coffey, David, Highfill, Steven L., Bucher, Christoph M., Matise, Ilze, Morse, Herbert C., O’Sullivan, M. Gerard, Schutten, Melissa, Johnson, Charles, Bellgrau, Donald, Blazar, Bruce R., Modiano, Jaime F.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063948/
https://ncbi.nlm.nih.gov/pubmed/24945807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100629
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