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Isolation of single-base genome-edited human iPS cells without antibiotic selection
Precise editing of human genomes in pluripotent stem cells by homology-driven repair of targeted nuclease-induced cleavage has been hindered by the difficulty of isolating rare clones. We developed an efficient method to capture rare mutational events, enabling isolation of mutant lines with single-...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4063274/ https://ncbi.nlm.nih.gov/pubmed/24509632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2840 |
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