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Intrinsic Conformational Plasticity of Native EmrE Provides a Pathway for Multidrug Resistance

[Image: see text] EmrE is a multidrug resistance efflux pump with specificity to a wide range of antibiotics and antiseptics. To obtain atomic-scale insight into the attributes of the native state that encodes the broad specificity, we used a hybrid of solution and solid-state NMR methods in lipid b...

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Hlavní autoři: Cho, Min-Kyu, Gayen, Anindita, Banigan, James R., Leninger, Maureen, Traaseth, Nathaniel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063181/
https://ncbi.nlm.nih.gov/pubmed/24856154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja503145x
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