The role of plasma membrane STIM1 and Ca(2 +)entry in platelet aggregation. STIM1 binds to novel proteins in human platelets

Ca(2 +) elevation is essential to platelet activation. STIM1 senses Ca(2 +) in the endoplasmic reticulum and activates Orai channels allowing store-operated Ca(2 +) entry (SOCE). STIM1 has also been reported to be present in the plasma membrane (PM) with its N-terminal region exposed to the outside...

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Main Authors: Ambily, A., Kaiser, W.J., Pierro, C., Chamberlain, E.V., Li, Z., Jones, C.I., Kassouf, N., Gibbins, J.M., Authi, K.S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Ltd 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062937/
https://ncbi.nlm.nih.gov/pubmed/24308967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.11.025
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