Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction

Controlled mechanical ventilation (CMV) is associated with the development of diaphragm atrophy and contractile dysfunction, and respiratory muscle weakness is thought to contribute significantly to delayed weaning of patients. Therefore, therapeutic strategies for preventing these processes may hav...

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Bibliografiske detaljer
Main Authors: Smith, Ira J., Godinez, Guillermo L., Singh, Baljit K., McCaughey, Kelly M., Alcantara, Raniel R., Gururaja, Tarikere, Ho, Melissa S., Nguyen, Henry N., Friera, Annabelle M., White, Kathy A., McLaughlin, John R., Hansen, Derek, Romero, Jason M., Baltgalvis, Kristen A., Claypool, Mark D., Li, Wei, Lang, Wayne, Yam, George C., Gelman, Marina S., Ding, Rongxian, Yung, Stephanie L., Creger, Daniel P., Chen, Yan, Singh, Rajinder, Smuder, Ashley J., Wiggs, Michael P., Kwon, Oh-Sung, Sollanek, Kurt J., Powers, Scott K., Masuda, Esteban S., Taylor, Vanessa C., Payan, Donald G., Kinoshita, Taisei, Kinsella, Todd M.
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2014
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062832/
https://ncbi.nlm.nih.gov/pubmed/24671708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-244210
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