Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction

Controlled mechanical ventilation (CMV) is associated with the development of diaphragm atrophy and contractile dysfunction, and respiratory muscle weakness is thought to contribute significantly to delayed weaning of patients. Therefore, therapeutic strategies for preventing these processes may hav...

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Main Authors: Smith, Ira J., Godinez, Guillermo L., Singh, Baljit K., McCaughey, Kelly M., Alcantara, Raniel R., Gururaja, Tarikere, Ho, Melissa S., Nguyen, Henry N., Friera, Annabelle M., White, Kathy A., McLaughlin, John R., Hansen, Derek, Romero, Jason M., Baltgalvis, Kristen A., Claypool, Mark D., Li, Wei, Lang, Wayne, Yam, George C., Gelman, Marina S., Ding, Rongxian, Yung, Stephanie L., Creger, Daniel P., Chen, Yan, Singh, Rajinder, Smuder, Ashley J., Wiggs, Michael P., Kwon, Oh-Sung, Sollanek, Kurt J., Powers, Scott K., Masuda, Esteban S., Taylor, Vanessa C., Payan, Donald G., Kinoshita, Taisei, Kinsella, Todd M.
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2014
Teme:
Research Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062832/
https://ncbi.nlm.nih.gov/pubmed/24671708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-244210
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