Paxillin mediates stretch-induced Rho signaling and endothelial permeability via assembly of paxillin-p42/44MAPK-GEF-H1 complex

Suboptimal ventilator support or regional ventilation heterogeneity in inflamed lungs causes excessive tissue distension, which triggers stretch-induced pathological signaling and may lead to vascular leak and lung dysfunction. Focal adhesions (FAs) are cell-substrate adhesive complexes participatin...

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Autori principali: Gawlak, Grzegorz, Tian, Yufeng, O'Donnell, James J., Tian, Xinyong, Birukova, Anna A., Birukov, Konstantin G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2014
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062829/
https://ncbi.nlm.nih.gov/pubmed/24706358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-245142
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