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N-Demethylation and N-oxidation of imipramine in rat thoracic aortic endothelial cells

The aim of this study was to examine whether cultured rat thoracic aortic endothelial cells (TAECs) have the ability to metabolize the tertiary amine, imipramine. In rat TAECs, imipramine was biotransformed into N-demethylate and N-oxide by cytochrome P450 (CYP) and flavin-containing monooxygenase (...

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Bibliografiske detaljer
Main Authors: Ueda, Yukari, Yaginuma, Toshihiko, Sakurai, Eiko, Sakurai, Eiichi
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062819/
https://ncbi.nlm.nih.gov/pubmed/24647745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11626-014-9739-0
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