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The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R-ratio). A population study.

The metabolism of imipramine was investigated in 106 healthy volunteers, all having a sparteine metabolic ratio (MR) of 0.2-0.5 and hence classified as extensive metabolisers. Each subject was given a single oral dose of 25 mg imipramine hydrochloride and blood for assays of imipramine and metabolit...

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Detalhes bibliográficos
Main Authors: Skjelbo, E, Gram, L F, Brøsen, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1381588/
https://ncbi.nlm.nih.gov/pubmed/8471415
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