MicroRNA Profiling in Muc2 Knockout Mice of Colitis-Associated Cancer Model Reveals Epigenetic Alterations during Chronic Colitis Malignant Transformation

Our previous studies have demonstrated that genetic deletion of the Muc2 gene causes colorectal cancers in mice. The current study further showed that at the early stage (<3 months) the Muc2 knockout mice spontaneously developed chronic inflammation in colon and rectum, similar pathological featu...

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Détails bibliographiques
Auteurs principaux: Bao, Yonghua, Guo, Yongchen, Li, Zexin, Fang, Wenfeng, Yang, Yiqiong, Li, Xuhan, Li, Zhuangzhuang, Xiong, Bowen, Chen, Zhiguo, Wang, Jianguo, Kang, Kang, Gou, Deming, Yang, Wancai
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062425/
https://ncbi.nlm.nih.gov/pubmed/24941171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099132
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