MicroRNA Profiling in Muc2 Knockout Mice of Colitis-Associated Cancer Model Reveals Epigenetic Alterations during Chronic Colitis Malignant Transformation

Our previous studies have demonstrated that genetic deletion of the Muc2 gene causes colorectal cancers in mice. The current study further showed that at the early stage (<3 months) the Muc2 knockout mice spontaneously developed chronic inflammation in colon and rectum, similar pathological featu...

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Detalhes bibliográficos
Main Authors: Bao, Yonghua, Guo, Yongchen, Li, Zexin, Fang, Wenfeng, Yang, Yiqiong, Li, Xuhan, Li, Zhuangzhuang, Xiong, Bowen, Chen, Zhiguo, Wang, Jianguo, Kang, Kang, Gou, Deming, Yang, Wancai
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062425/
https://ncbi.nlm.nih.gov/pubmed/24941171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099132
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