Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour

Wilms tumour (WT) is an embryonal kidney neoplasia for which very few driver genes have been identified. Here we identify DROSHA mutations in 12% of WT samples (26/222) using whole-exome sequencing and targeted sequencing of 10 microRNA (miRNA)-processing genes. A recurrent mutation (E1147K) affecti...

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Hauptverfasser: Torrezan, Giovana T., Ferreira, Elisa N., Nakahata, Adriana M., Barros, Bruna D. F., Castro, Mayra T. M., Correa, Bruna R., Krepischi, Ana C. V., Olivieri, Eloisa H. R., Cunha, Isabela W., Tabori, Uri, Grundy, Paul E., Costa, Cecilia M. L., de Camargo, Beatriz, Galante, Pedro A. F., Carraro, Dirce M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062040/
https://ncbi.nlm.nih.gov/pubmed/24909261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5039
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