Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour

Wilms tumour (WT) is an embryonal kidney neoplasia for which very few driver genes have been identified. Here we identify DROSHA mutations in 12% of WT samples (26/222) using whole-exome sequencing and targeted sequencing of 10 microRNA (miRNA)-processing genes. A recurrent mutation (E1147K) affecti...

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主要な著者: Torrezan, Giovana T., Ferreira, Elisa N., Nakahata, Adriana M., Barros, Bruna D. F., Castro, Mayra T. M., Correa, Bruna R., Krepischi, Ana C. V., Olivieri, Eloisa H. R., Cunha, Isabela W., Tabori, Uri, Grundy, Paul E., Costa, Cecilia M. L., de Camargo, Beatriz, Galante, Pedro A. F., Carraro, Dirce M.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Pub. Group 2014
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Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062040/
https://ncbi.nlm.nih.gov/pubmed/24909261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5039
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