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Epigenetic Manipulation of a Filamentous Fungus by the Proteasome-Inhibitor Bortezomib Induces the Production of an Additional Secondary Metabolite

The use of epigenetic modifiers, such as histone deacetylase inhibitors and DNA methyltransferase inhibitors, has been explored increasingly as a technique to induce the production of additional microbial secondary metabolites. The application of such molecules to microbial cultures has been shown t...

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Bibliographic Details
Main Authors: VanderMolen, Karen M., Darveaux, Blaise A., Chen, Wei-Lun, Swanson, Steven M., Pearce, Cedric J., Oberlies, Nicholas H.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4061710/
https://ncbi.nlm.nih.gov/pubmed/24955237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4RA00274A
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