A Mechanistic and Structural Investigation of Modified Derivatives of the Diaryltriazine Class of NNRTIs Targeting HIV-1 Reverse Transcriptase

BACKGROUND: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are vital in treating HIV-1 infection by inhibiting reverse transcriptase (RT). Drug toxicity and resistance drive the need for effective new inhibitors with improved physiochemical properties and potent antiviral activity. Compute...

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Hauptverfasser: Mislak, Andrea C., Frey, Kathleen M., Bollini, Mariela, Jorgensen, William L., Anderson, Karen S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4061246/
https://ncbi.nlm.nih.gov/pubmed/24726448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2014.04.001
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