Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity

[Image: see text] Both c-Met and VEGFR-2 are important targets for cancer therapies. Here we report a series of potent dual c-Met and VEGFR-2 inhibitors bearing an anilinopyrimidine scaffold. Two novel synthetic protocols were employed for rapid analoguing of the designed molecules for structure–act...

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Main Authors: Zhan, Zhengsheng, Ai, Jing, Liu, Qiufeng, Ji, Yinchun, Chen, Tiantian, Xu, Yechun, Geng, Meiyu, Duan, Wenhu
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060942/
https://ncbi.nlm.nih.gov/pubmed/24944742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500066m
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