Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy

[Image: see text] In an effort to develop potent, orally bioavailable compounds for the treatment of neoplastic diseases, we developed a class of dual VEGFR-2 kinase and tubulin inhibitors. Targeting the VEGFR receptor kinase and tubulin structure allows for inhibition of both tumor cells and tumor...

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Main Authors: Chekler, Eugene L. Piatnitski, Kiselyov, Alexander S., Ouyang, Xiaohu, Chen, Xiaoling, Pattaropong, Vatee, Wang, Ying, Tuma, M. Carolina, Doody, Jacqueline F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2010
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007844/
https://ncbi.nlm.nih.gov/pubmed/24900236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1001568
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