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A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes: IL-27 inhibits activation induced T cell death
IL-27, an IL-12 family cytokine, has pleiotropic functions in the differentiation and expansion of CD4(+) T cell subsets. Here, we discovered a novel function of IL-27. CD4(+)CD45RB(high) T cells from mice deficient for the α chain of IL-27 receptor failed to induce colitis in Rag(−/−) recipients, b...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4060896/ https://ncbi.nlm.nih.gov/pubmed/23335749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201017 |
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