Transcriptional Reprogramming of Mature CD4(+) T helper Cells generates distinct MHC class II-restricted Cytotoxic T Lymphocytes

TCRαβ thymocytes differentiate to either CD8αβ cytotoxic T lymphocytes or CD4(+) T helper cells. This functional dichotomy is controlled by key transcription factors, including the T helper master regulator, ThPOK, which suppresses the cytolytic program in MHC class II-restricted CD4(+) thymocytes....

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Main Authors: Mucida, Daniel, Husain, Mohammad Mushtaq, Muroi, Sawako, van Wijk, Femke, Shinnakasu, Ryo, Naoe, Yoshinori, Reis, Bernardo Sgarbi, Huang, Yujun, Lambolez, Florence, Docherty, Michael, Attinger, Antoine, Shui, Jr-Wen, Kim, Gisen, Lena, Christopher J., Sakaguchi, Shinya, Miyamoto, Chizuko, Wang, Peng, Atarashi, Koji, Park, Yunji, Nakayama, Toshinori, Honda, Kenya, Ellmeier, Wilfried, Kronenberg, Mitchell, Taniuchi, Ichiro, Cheroutre, Hilde
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581083/
https://ncbi.nlm.nih.gov/pubmed/23334788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2523
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