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Up-regulation of glycolytic metabolism is required for HIF1α-driven bone formation
The bone marrow environment is among the most hypoxic in the body, but how hypoxia affects bone formation is not known. Because low oxygen tension stabilizes hypoxia-inducible factor alpha (HIFα) proteins, we have investigated the effect of expressing a stabilized form of HIF1α in osteoblast precurs...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4060724/ https://ncbi.nlm.nih.gov/pubmed/24912186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1324290111 |
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