Up-regulation of glycolytic metabolism is required for HIF1α-driven bone formation

The bone marrow environment is among the most hypoxic in the body, but how hypoxia affects bone formation is not known. Because low oxygen tension stabilizes hypoxia-inducible factor alpha (HIFα) proteins, we have investigated the effect of expressing a stabilized form of HIF1α in osteoblast precurs...

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Bibliographic Details
Main Authors: Regan, Jenna N., Lim, Joohyun, Shi, Yu, Joeng, Kyu Sang, Arbeit, Jeffrey M., Shohet, Ralph V., Long, Fanxin
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060724/
https://ncbi.nlm.nih.gov/pubmed/24912186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1324290111
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