Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism

Voltage-gated sodium channels are important targets for the development of pharmaceutical drugs, because mutations in different human sodium channel isoforms have causal relationships with a range of neurological and cardiovascular diseases. In this study, functional electrophysiological studies sho...

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Bibliografiske detaljer
Main Authors: Bagnéris, Claire, DeCaen, Paul G., Naylor, Claire E., Pryde, David C., Nobeli, Irene, Clapham, David E., Wallace, B. A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060673/
https://ncbi.nlm.nih.gov/pubmed/24850863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406855111
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