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Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses

Ketamine is an NMDA receptor (NMDAR) antagonist that elicits rapid antidepressant responses in patients with treatment-resistant depression. However, ketamine can also produce psychotomimetic effects that limit its utility as an antidepressant, raising the question of whether the clinically tolerate...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gideons, Erinn S., Kavalali, Ege T., Monteggia, Lisa M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060670/
https://ncbi.nlm.nih.gov/pubmed/24912158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323920111
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