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Hsp104 Overexpression Cures Saccharomyces cerevisiae [PSI(+)] by Causing Dissolution of the Prion Seeds

The [PSI(+)] yeast prion is formed when Sup35 misfolds into amyloid aggregates. [PSI(+)], like other yeast prions, is dependent on the molecular chaperone Hsp104, which severs the prion seeds so that they pass on as the yeast cells divide. Surprisingly, however, overexpression of Hsp104 also cures [...

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Autors principals: Park, Yang-Nim, Zhao, Xiaohong, Yim, Yang-In, Todor, Horia, Ellerbrock, Robyn, Reidy, Michael, Eisenberg, Evan, Masison, Daniel C., Greene, Lois E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060481/
https://ncbi.nlm.nih.gov/pubmed/24632242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00300-13
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