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Hsp104 Overexpression Cures Saccharomyces cerevisiae [PSI(+)] by Causing Dissolution of the Prion Seeds
The [PSI(+)] yeast prion is formed when Sup35 misfolds into amyloid aggregates. [PSI(+)], like other yeast prions, is dependent on the molecular chaperone Hsp104, which severs the prion seeds so that they pass on as the yeast cells divide. Surprisingly, however, overexpression of Hsp104 also cures [...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4060481/ https://ncbi.nlm.nih.gov/pubmed/24632242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00300-13 |
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