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Hsp104 Overexpression Cures Saccharomyces cerevisiae [PSI(+)] by Causing Dissolution of the Prion Seeds

The [PSI(+)] yeast prion is formed when Sup35 misfolds into amyloid aggregates. [PSI(+)], like other yeast prions, is dependent on the molecular chaperone Hsp104, which severs the prion seeds so that they pass on as the yeast cells divide. Surprisingly, however, overexpression of Hsp104 also cures [...

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書誌詳細
主要な著者: Park, Yang-Nim, Zhao, Xiaohong, Yim, Yang-In, Todor, Horia, Ellerbrock, Robyn, Reidy, Michael, Eisenberg, Evan, Masison, Daniel C., Greene, Lois E.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060481/
https://ncbi.nlm.nih.gov/pubmed/24632242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00300-13
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