A genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis

INTRODUCTION: Progression of joint destruction in rheumatoid arthritis (RA) is partly heritably; 45 to 58% of the variance in joint destruction is estimated to be explained by genetic factors. The binding of RANKL (Receptor Activator for Nuclear Factor κ B Ligand) to RANK results in the activation o...

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Main Authors: Knevel, Rachel, de Rooy, Diederik PC, Saxne, Tore, Lindqvist, Elisabet, Leijsma, Martha K, Daha, Nina A, Koeleman, Bobby PC, Tsonaka, Roula, Houwing-Duistermaat, Jeanine J, Schonkeren, Joris JM, Toes, Rene EM, Huizinga, Tom WJ, Brouwer, Elisabeth, Wilson, Anthony G, van der Helm-van Mil, Annette HM
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060386/
https://ncbi.nlm.nih.gov/pubmed/24886600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4558
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