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CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction

INTRODUCTION: NLRP3 plays a role in sensing various pathogen components or stresses in the innate immune system. Once activated, NLRP3 associates with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and procaspase-1 to form a large protein complex termed inflamm...

詳細記述

保存先:
書誌詳細
主要な著者: Ito, Sayaka, Hara, Yukichi, Kubota, Tetsuo
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060228/
https://ncbi.nlm.nih.gov/pubmed/24517500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4483
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