Paroxysmal nocturnal hemoglobinuria with copy number-neutral 6pLOH in GPI (+) but not in GPI (−) granulocytes

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired bone marrow disorder caused by expansion of a clone of hematopoietic cells lacking glycosylphosphatidylinositol (GPI)-anchored membrane proteins. Multiple lines of evidence suggest immune attack on normal hematopoietic stem cells provides a se...

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Bibliographic Details
Main Authors: Ueda, Yasutaka, Nishimura, Jun-ichi, Murakami, Yoshiko, Kajigaya, Sachiko, Kinoshita, Taroh, Kanakura, Yuzuru, Young, Neal S.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060154/
https://ncbi.nlm.nih.gov/pubmed/24931618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejh.12253
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