Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH)

Somatic mutation of PIGA in hematopoietic stem cells causes deficiency of glycosyl phosphatidylinositol–anchored proteins in paroxysmal nocturnal hemoglobinuria (PNH) that underlies the intravascular hemolysis but does not account for expansion of the PNH clone. Immune mechanisms may mediate clonal...

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Detalhes bibliográficos
Main Authors: Inoue, Norimitsu, Izui-Sarumaru, Tomohisa, Murakami, Yoshiko, Endo, Yuichi, Nishimura, Jun-Ichi, Kurokawa, Ken, Kuwayama, Maki, Shime, Hiroaki, Machii, Takashi, Kanakura, Yuzuru, Meyers, Gabrielle, Wittwer, Carl, Chen, Zhong, Babcock, William, Frei-Lahr, Debra, Parker, Charles J., Kinoshita, Taroh
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Red Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895453/
https://ncbi.nlm.nih.gov/pubmed/16940417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-025148
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