Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH)

Somatic mutation of PIGA in hematopoietic stem cells causes deficiency of glycosyl phosphatidylinositol–anchored proteins in paroxysmal nocturnal hemoglobinuria (PNH) that underlies the intravascular hemolysis but does not account for expansion of the PNH clone. Immune mechanisms may mediate clonal...

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Autors principals: Inoue, Norimitsu, Izui-Sarumaru, Tomohisa, Murakami, Yoshiko, Endo, Yuichi, Nishimura, Jun-Ichi, Kurokawa, Ken, Kuwayama, Maki, Shime, Hiroaki, Machii, Takashi, Kanakura, Yuzuru, Meyers, Gabrielle, Wittwer, Carl, Chen, Zhong, Babcock, William, Frei-Lahr, Debra, Parker, Charles J., Kinoshita, Taroh
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2006
Matèries:
Red Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895453/
https://ncbi.nlm.nih.gov/pubmed/16940417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-025148
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