Lassomycin, a ribosomally synthesized cyclic peptide, kills Mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2

Languishing antibiotic discovery and flourishing antibiotic resistance have prompted development of alternative untapped sources for antibiotic discovery, including previously uncultured bacteria. Here, we screen extracts from uncultured species against M. tuberculosis and identify lassomycin, an an...

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Hlavní autoři: Gavrish, Ekaterina, Sit, Clarissa S., Cao, Shugeng, Kandror, Olga, Spoering, Amy, Peoples, Aaron, Ling, Losee, Fetterman, Ashley, Hughes, Dallas, Bissell, Anthony, Torrey, Heather, Akopian, Tatos, Mueller, Andreas, Epstein, Slava, Goldberg, Alfred, Clardy, Jon, Lewis, Kim
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060151/
https://ncbi.nlm.nih.gov/pubmed/24684906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.01.014
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