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Improved Histone Deacetylase Inhibitors as Therapeutics for the Neurodegenerative Disease Friedreich's Ataxia: A New Synthetic Route

Friedreich's ataxia (FRDA) is caused by transcriptional repression of the nuclear FXN gene encoding the essential mitochondrial protein frataxin. Based on the hypothesis that the acetylation state of the histone proteins is responsible for gene silencing in FRDA, previous work in our lab identi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xu, Chunping, Soragni, Elisabetta, Jacques, Vincent, Rusche, James R., Gottesfeld, Joel M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060102/
https://ncbi.nlm.nih.gov/pubmed/27721337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph4121578
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