Endostatin and kidney fibrosis in aging: a case for antagonistic pleiotropy?

A recurring theme of a host of gerontologic studies conducted in either experimental animals or in humans is related to documenting the functional decline with age. We hypothesize that elevated circulating levels of a powerful antiangiogenic peptide, endostatin, represent one of the potent systemic...

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Bibliographic Details
Main Authors: Lin, Chi Hua Sarah, Chen, Jun, Ziman, Bruce, Marshall, Shannon, Maizel, Julien, Goligorsky, Michael S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
Subjects:
Integrative Cardiovascular Physiology and Pathophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059979/
https://ncbi.nlm.nih.gov/pubmed/24727495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00064.2014
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