Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney

Endostatin (EST), an anti-angiogenic factor, is enriched in aging kidneys. EST is also an interactive partner of transglutaminase 2 (TG2), an enzyme that cross-links extracellular matrix proteins. Here we tested whether EST and TG2 play a role in the fibrosis of aging. In wild type mice, aging kidne...

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Veröffentlicht in:Kidney Int
Hauptverfasser: Lin, Chi Hua Sarah, Chen, Jun, Zhang, Zhongtao, Johnson, Gail, Cooper, Arthur JL, Feola, Julianne, Bank, Alexander, Shein, Jonathan, Ruotsalainen, Heli, Pihlajaniemi, Taina, Goligorsky, Michael S
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868664/
https://ncbi.nlm.nih.gov/pubmed/27165830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2016.01.030
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