A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome

Efficient duplication of the genome requires the concerted action of helicase and DNA polymerases at replication forks(1), to avoid stalling of the replication machinery and consequent genomic instability(2-4). In eukaryotes, the physical coupling between helicase and DNA polymerases remains poorly...

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Main Authors: Simon, Aline C., Zhou, Jin C., Perera, Rajika L., van Deursen, Frederick, Evrin, Cecile, Ivanova, Marina E., Kilkenny, Mairi L., Renault, Ludovic, Kjaer, Svend, Matak-Vinković, Dijana, Labib, Karim, Costa, Alessandro, Pellegrini, Luca
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059944/
https://ncbi.nlm.nih.gov/pubmed/24805245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13234
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