Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells

Coeliac disease (CD), an enteropathy caused by cereal gluten ingestion, is characterized by CD4(+) T cells recognizing deamidated gluten and by antibodies reactive to gluten or the self-antigen transglutaminase 2 (TG2). TG2-specific immunoglobulin A (IgA) of plasma cells (PCs) from CD lesions have l...

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Detalhes bibliográficos
Main Authors: Steinsbø, Øyvind, Dunand, Carole J. Henry, Huang, Min, Mesin, Luka, Salgado-Ferrer, Marlene, Lundin, Knut E. A., Jahnsen, Jørgen, Wilson, Patrick C., Sollid, Ludvig M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059925/
https://ncbi.nlm.nih.gov/pubmed/24909383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5041
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