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PRECLINICAL EVALUATION OF THE COMBINATION OF mTOR AND PROTEASOME INHIBITORS WITH RADIOTHERAPY IN MALIGNANT PERIPHERAL NERVE SHEATH TUMORS
About one half of malignant peripheral nerve sheath tumors (MPNST) have Neurofibromin 1 (NF1) mutations. NF1 is a tumor suppressor gene essential for negative regulation of RAS signaling. Survival for MPNST patients is poor and we sought to identify an effective combination therapy. Starting with th...
Gorde:
| Egile Nagusiak: | , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2014
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4059766/ https://ncbi.nlm.nih.gov/pubmed/24668609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-014-1422-5 |
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