Total Synthesis of the Antitumor Natural Product Polycarcin V and Evaluation of Its DNA Binding Profile

[Image: see text] The convergent total synthesis of polycarcin V, a gilvocarcin-type natural product that shows significant cytotoxicity with selectivity for nonsmall-cell lung cancer, breast cancer, and melanoma cells, has been achieved in 13 steps from 7, 8, and 22; the sequence features a stereos...

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Hlavní autoři: Cai, Xiao, Ng, Kevin, Panesar, Harmanpreet, Moon, Seong-Jin, Paredes, Maria, Ishida, Keishi, Hertweck, Christian, Minehan, Thomas G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059221/
https://ncbi.nlm.nih.gov/pubmed/24824354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol501095w
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