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Total Synthesis of the Antitumor Natural Product Polycarcin V and Evaluation of Its DNA Binding Profile
[Image: see text] The convergent total synthesis of polycarcin V, a gilvocarcin-type natural product that shows significant cytotoxicity with selectivity for nonsmall-cell lung cancer, breast cancer, and melanoma cells, has been achieved in 13 steps from 7, 8, and 22; the sequence features a stereos...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4059221/ https://ncbi.nlm.nih.gov/pubmed/24824354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol501095w |
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