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Interaction with the adaptor protein Shc prevents aberrant Erk activation in the absence of extracellular stimulus
Control mechanisms that prevent aberrant signaling are necessary to maintain cellular homeostasis. We describe a novel mechanism by which the adaptor protein Shc binds directly to the MAP-kinase Erk, preventing its activation in the absence of extracellular stimulus. The Shc–Erk complex restricts Er...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4059177/ https://ncbi.nlm.nih.gov/pubmed/23584453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2557 |
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