UVA Light-excited Kynurenines Oxidize Ascorbate and Modify Lens Proteins through the Formation of Advanced Glycation End Products: IMPLICATIONS FOR HUMAN LENS AGING AND CATARACT FORMATION

Advanced glycation end products (AGEs) contribute to lens protein pigmentation and cross-linking during aging and cataract formation. In vitro experiments have shown that ascorbate (ASC) oxidation products can form AGEs in proteins. However, the mechanisms of ASC oxidation and AGE formation in the h...

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Hlavní autoři: Linetsky, Mikhail, Raghavan, Cibin T., Johar, Kaid, Fan, Xingjun, Monnier, Vincent M., Vasavada, Abhay R., Nagaraj, Ram H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059152/
https://ncbi.nlm.nih.gov/pubmed/24798334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.554410
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