A Novel Intracellular Peptide Derived from G(1)/S Cyclin D2 Induces Cell Death

Intracellular peptides are constantly produced by the ubiquitin-proteasome system, and many are probably functional. Here, the peptide WELVVLGKL (pep5) from G(1)/S-specific cyclin D2 showed a 2-fold increase during the S phase of HeLa cell cycle. pep5 (25–100 μm) induced cell death in several tumor...

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Autori principali: de Araujo, Christiane B., Russo, Lilian C., Castro, Leandro M., Forti, Fábio L., do Monte, Elisabete R., Rioli, Vanessa, Gozzo, Fabio C., Colquhoun, Alison, Ferro, Emer S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059116/
https://ncbi.nlm.nih.gov/pubmed/24764300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.537118
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