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Thymidine phosphorylase expression is associated with time to progression in patients with metastatic colorectal cancer
BACKGROUND: 5-Fluorouracil (5-FU) is the cornerstone of chemotherapeutic treatment for patients with colorectal cancer. The enzyme thymidine phosphorylase (TP) catalyzes the conversion of 5-FU to its active metabolite, 5-fluoro-2’-deoxyuridine. TP is expressed in tumour epithelial cells and stromal...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4058433/ https://ncbi.nlm.nih.gov/pubmed/24936150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6890-14-25 |
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