Antagonism of WT1 activity by protein self-association.

Germline loss-of-function mutations at the Wilms tumor (WT) suppressor locus WT1 are associated with a predisposition to WTs and mild genital system anomalies. In contrast, germ-line missense mutations within the WT1 gene encoding the DNA-binding domain often yield a more severe phenotype consisting...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Moffett, P, Bruening, W, Nakagama, H, Bardeesy, N, Housman, D, Housman, D E, Pelletier, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40580/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479946/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.11105
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