Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition.

An in vitro selection technique was used to identify a specific high-affinity DNA ligand targeted to human neutrophil elastase (HNE). 1H NMR data and a comparative analysis of the selected sequences suggest that the DNA folds into a G-quartet structure with duplexed ends. The high-affinity binding D...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Lin, Y, Padmapriya, A, Morden, K M, Jayasena, S D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40567/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479933/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.11044
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