Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition.

An in vitro selection technique was used to identify a specific high-affinity DNA ligand targeted to human neutrophil elastase (HNE). 1H NMR data and a comparative analysis of the selected sequences suggest that the DNA folds into a G-quartet structure with duplexed ends. The high-affinity binding D...

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Bibliografski detalji
Glavni autori: Lin, Y, Padmapriya, A, Morden, K M, Jayasena, S D
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC40567/
https://ncbi.nlm.nih.gov/pubmed/7479933
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