Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition.
An in vitro selection technique was used to identify a specific high-affinity DNA ligand targeted to human neutrophil elastase (HNE). 1H NMR data and a comparative analysis of the selected sequences suggest that the DNA folds into a G-quartet structure with duplexed ends. The high-affinity binding D...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1995
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40567/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479933/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.11044 |
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